Blar i forfatter "Zykova, Svetlana N."

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    • Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis 

      Tveita, Anders Aune; Rekvig, Ole Petter; Zykova, Svetlana N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-01)
      Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex deposition. It has been speculated that alterations in the synthesis or ...

    • Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis 

      Zykova, Svetlana N.; Tveita, Anders Aune; Rekvig, Ole Petter (Tidsskriftartikkel; Peer reviewed; Journal article, 2010-08-10)
      Background: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice. As this may represent a basic mechanism in the progression of lupus nephritis, several aspects of ...